Synthetic biology and principles of biological design
Synthetic Biology implements new functionalities through the use of rational design of cellular circuits. The implementation of complex dynamics such as oscillators, band detectors or signal amplifiers are paving the way for veritable cellular computing. However, adverse effects such as the genetic and metabolic load, signal/noise ratio of the systems or component orthogonality still require solutions for an effective engineering.
Aim
Identify how evolution has overcome design issues by studying the cellular circuits that govern above mentioned processes in order to find patterns and architectures beyond their molecular details
Generation of bioinspired minimal cellular circuits able to generate target behaviors (oscillators, signal amplification against noise…) by building minimal mathematical models that capture the dynamics of such systems. The mathematical analysis and model refinement will give way to its experimental validation, evidencing architectures capable of reproducing non-trivial dynamics.
Dealing with the genetic load in bacterial synthetic biology circuits: convergences with the Ohm’s law.
Carbonell-Ballestero M, Garcia-Ramallo E, Montañez R, Rodriguez-Caso C, Macía J.
Nucleic acids research., 2016 Jan 8;44(1):496-507..
A bottom-up characterization of transfer functions for synthetic biology designs: lessons from enzymology.
Carbonell-Ballestero M, Duran-Nebreda S, Montanez R, Solé R, Macía J, Rodríguez-Caso C.
Nucleic acids research., 2014 Dec 16;42(22):14060-9..
PID2020-119538RB-I00
Nueva tecnología para la creación de biocircuitos computacionales reprogramables.
2021-2024. 54.450 EUR. Investigador Principal Consolidado.
MICINN
