Pharmacological modulation of angiogenesis
Angiogenesis (the formation of blood vessels from pre-existing vascular plexus) is a finely controlled physiological process, the dysregulation of which is associated with numerous diseases, such as cancer, atherosclerosis, rheumatoid arthritis or diabetic retinopathy. Therefore, pharmacological modulation of angiogenesis represents a therapeutic approach to these diseases.
Aim
Discovery of natural or synthetic molecules with angiogenesis modulating activity and characterization of their molecular mechanisms of action.
We make use of a wide variety of in vitro assays to study the different steps of the angiogenesis process, using primary human endothelial cells. We also use in vivo assays in different animal models (mouse, chick embryo and zebrafish) to evaluate the angiogenesis modulating activity of the compounds.
Characterization of the activity and the mechanism of action of a new toluquinol derivative with improved potential as an antiangiogenic drug.
Torres-Vargas, J. A., Cheng-Sánchez, I., Martínez-Poveda, B., Medina, M. Á., Sarabia, F., García-Caballero, M., & Quesada, A. R.
Biomedicine & Pharmacotherapy, 155, 113759. (2022).
Antiangiogenic Phytochemicals Constituent of Diet as Promising Candidates for Chemoprevention of Cancer.
Marrero, A. D., Quesada, A. R., Martínez-Poveda, B., & Medina, M. Á.
Antioxidants (Basel, Switzerland), 11(2), 302(2022) .
Non-targeted metabolomics characterization of Annona muricata leaf extracts with anti-angiogenic activity.
Cárdenas, C., Torres-Vargas, J. A., Cárdenas-Valdivia, A., Jurado, N., Quesada, A. R., García-Caballero, M., Martínez-Poveda, B., & Medina, M. Á.
Biomedicine & Pharmacotherapy, 144, 112263 (2021) .
A comparative study of the antiangiogenic activity of hydroxytyrosyl alkyl ethers.
Marrero, A. D., Castilla, L., Espartero, J. L., Madrona, A., R Quesada, A., Medina, M. Á., & Martínez-Poveda, B.
Food Chemistry, 333, 127476. .
PY20_00257
Inhibición de la Linf/angiogénesis Patológica: Búsqueda y Caracterización de Nuevos y Mejores Fármacos, e Identificación de Nuevas Estrategias Terapéuticas.
Enero 2021 - Junio 2023
Junta de Andalucía – FEDER
PID2019-105010RB-I00
Angiogenesis, inflammation and metabolism as therapeutic targets for pathological angiogenesis using biotechnological approaches.
Enero 2020 - Diciembre 2022
MICINN
P12-CTS-1507
Búsqueda y caracterización de nuevos fármacos inhibidores de la angiogénesis.
Enero 2014 - Diciembre 2017
Junta de Andalucía – FEDER
BIO2014-56092-R
Búsqueda de nuevas herramientas de intervención terapéutica para el control de la angiogénesis patológica.
Enero 2015 - Diciembre 2018
MINECO – FEDER
