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M. Gonzalo Claros

My research is fully based on bioinformatics to study gene expression, transcriptomics and genomes. From 2007 to 2022 I lead the research of the Bioinformatics Andalusian Platform (http://www.scbi.uma.es), were automated solutions using workflow managers were proposed for detection of differentially expressed genes using microarrays and RNA-seq, genome and transcriptome assembling of non-model organisms (olive, faba bean, pine, argan, chestnut, vine, sole, etc), functional interpretations and networking. After my involvement in the IHSM, I am devoted to mitigation of climate changes on olive and citrus fruit yields. As a member of IBIMA and CIBERER, I was interested in the identification of new biomarkers for lung cancer useful for liquid biopsies.

  • Aguilera-Cobos L, García-Sanz P, Rosario-Lozano MP, M.G. Claros, Blasco-Amaro JA (2023) An innovative framework to determine the implementation level of personalized medicine: A systematic review. Front. Public Health 11:1039688. DOI: 10.3389/fpubh.2023.1039688 (2296-2565)
  • E. Espinosa, M. Arroyo, R. Larrosa, J. Gomez-Maldonado, M.A. Cobo Dols, M.G. Claros, R. Bautista (2022) Construction of miRNA–mRNA networks for the identification of lung cancer biomarkers in liquid biopsies. Clin and Transl Oncol DOI: 10.1007/s12094-022-02969-7
  • M Sheikh-Assadi, R. Naderi, S. Alireza Salami, M. Kafi, R. Fatahi, V. Shariati, F. Martinelli, A. Cicatelli, M. Triassi, F. Guarino, G. Improta, M.G. Claros (2022) Normalized workflow to optimize hybrid de novo transcriptome assembly for huge-genome non-model species: a case study in Lilium ledebourii (Baker) Boiss. Plants-Basel 11(18): 2365. DOI: 10.3390/plants11182365
  • E. Díaz-Santiago, M.G. Claros, R. Yahyaoui, Y. de Diego-Otero, R. Calvo, J. Hoenicka, F. Palau, J.A.G. Ranea, J.R. Perkins (2021) Decoding neuromuscular disorders using phenotypic clusters obtained from co-occurrence networks. Frontiers in Molecular Biosciences, section Biological Modeling and Simulation, 8: 635074. DOI: 10.3389/fmolb.2021.635074
  • J. Córdoba-Caballero, P. Seoane, F.M. Jabato, J.R. Perkins, M. Manchado, M.G. Claros (2020) An improved de novo assembling and polishing of Solea senegalensis transcriptome shed light on retinoic acid signalling in larvae. Scientific Reports 10:20654. DOI: 10.1038/s41598-020-77201-z
  • A.P. Arce-Leal, R. Bautista, E.A. Rodríguez-Negrete, M.A. Manzanilla-Ramírez, J.J. Velázquez-Monreal, M.E. Santos-Cervantes, J. Méndez-Lozano, C.R. Beuzón, E.R. Bejarano, A.G. Castillo, M.G. Claros, N.E. Leyva-López (2020) Gene expression profile of Mexican lime (Citrus aurantifolia) trees in response to Huanglongbing disease caused by Candidatus Liberibacter asiaticus. Microorganisms 8(4): 528. DOI: 10.3390/microorganisms8040528
  • M. Arroyo, R. Larrosa, J. Gómez-Maldonado, M. Á. Cobo, M.G. Claros, R. Bautista (2020) Expression-based, consistent biomarkers for prognosis and diagnosis in lung cancer. Clin Translat Oncol 22: 1867–1874. DOI: 10.1007/s12094-020-02328-4
  • M. Arroyo, R. Bautista, R. Larrosa, M.Á. Cobo, M.G. Claros (2019) Biomarker potential of repetitive-element transcriptome in lung cancer. PeerJ 7: e8277. DOI: 10.7717/peerj.8277
  • S. González-Gordo, R. Bautista, M.G. Claros, A. Cañas, J.M. Palma, F.J. Corpas (2019) Nitric oxide-dependent regulation of sweet pepper fruit ripening. J. Exp. Bot. 70(17): 4557–4570. DOI: 10.1093/jxb/erz136
  • P. Seoane, S.T. Tapia-Paniagua, R. Bautista, E. Alcaide, C. Esteve, E. Martínez- Manzanares, M.C. Balebona, M.G. Claros, M.A. Moriñigo (2019) TarSynFlow, a workflow for bacterial genome comparisons that revealed genes putatively involved in the probiotic character of Shewanella putrefaciens strain Pdp11. PeerJ 7: e6526. DOI: 10.7717/peerj.6526
  • D Urda, F Aragón, R. Bautista, L Franco, F Veredas, M.G. Claros JM Jerez (2018) BLASSO: integration of biological knowledge into a regularized linear model. BMC Systems Biology 12: 94. DOI: 10.1186/s12918-018-0612-8
  • P Seoane, M Espigares, R Carmona, A Polonio, J Quintana, E Cretazzo, J Bota, A Pérez-García, JD Alché, L Gómez, M.G. Claros (2018) TransFlow: A modular frame- work for assembling and assessing accurate de novo transcriptomes in non-model organisms. BMC Bioinformatics 2018, 19: 416. DOI: 10.1186/s12859-018-2384-y
  • A Zafra, R Carmona, JA Traverso, J Hancock, MHS Goldman, M.G. Claros, SJ Hiscock, JD Alché (2017) Identification and functional annotation of genes differentially expressed in the reproductive tissues of the olive tree (Olea europaea L.) through the generation of subtractive libraries. Frontiers in Plant Science 8: 1576. DOI: 10.3389/fpls.2017.01576
  • R Carmona, M Arroyo, MJ Jiménez-Quesada, P Seoane, A Zafra, R Larrosa, JD Alché, M.G. Claros (2017) Automated identification of reference genes based on RNA-seq data. Biomedical Engineering Online 16: 65. DOI: 10.1186/s12938-017-0356-5
  • MJ Jimenez-Quesada, R Carmona, E Lima-Cabello, JÁ Traverso, AJ Castro, M.G. Claros, JD Alché (2017) Generation of nitric oxide by olive (Olea europaea L.) pollen during in vitro germination and assessment of the S-nitroso- and nitro- pollen proteomes by computational predictive methods. Nitric Oxide 68, 23-27. DOI: 10.1016/j.niox.2017.06.005