Identification of new antitumor molecules
Tumor development is linked to distinctive characteristics (hallmarks of cancer), with various processes involving different cell types in the tumor microenvironment: proliferation, angiogenesis, inflammation, metabolic reprogramming and cell fate dysregulation. The identification of molecules modulating these processes represents a pharmacological tool for cancer treatment.
Aim
Discovery and characterization of natural or synthetic molecules with antitumor activity in various processes and cell types of the tumor microenvironment.
We make use of a wide variety of in vitro assays to study the effects of compounds on processes linked to the tumor microenvironment (angiogenesis, inflammation, metabolism, autophagy…). We use a wide variety of human tumor lines, primary human endothelial cells and inflammatory cells. We also use animal models to monitor tumor growth.
The synthetic molecule stauprimide impairs cell growth and migration in triple-negative breast cancer.
Carrillo, P., Bernal, M. Téllez-Quijorna, C., Marrero, A.D., Vidal, I., Castilla, L., Caro, C., Domínguez, A., García-Martín, M.L., Quesada, A.R., Medina, M.Á., Martínez-Poveda, B.
Biomedicine & Pharmacotherapy , 158, 114070 (2023).
Glucose Favors Lipid Anabolic Metabolism in the Invasive Breast Cancer Cell Line MDA-MB-231.
Ocaña, M. C., Martínez-Poveda, B., Quesada, A. R., & Medina, M. Á.
Biology, 9(1), 16. (2020).
Metabolism within the tumor microenvironment and its implication on cancer progression: An ongoing therapeutic target.
Ocaña, M. C., Martínez-Poveda, B., Quesada, A. R., & Medina, M. Á.
Medicinal Research Reviews,, 39(1), 70–113 (2019).
PY20_00257
Inhibición de la Linf/angiogénesis Patológica: Búsqueda y Caracterización de Nuevos y Mejores Fármacos, e Identificación de Nuevas Estrategias Terapéuticas.
Enero 2021 - Junio 2023
Junta de Andalucía – FEDER
PID2019-105010RB-I00
Angiogenesis, inflammation and metabolism as therapeutic targets for pathological angiogenesis using biotechnological approaches.
Enero 2020 - Diciembre 2022
MICINN
Plan Propio IBIMA 2020
Estudio del potencial terapéutico de la estauprimida en cáncer de mama. Ayudas Investigadores Emergentes Área 2
2020
IBIMA
P12-CTS-1507
Búsqueda y caracterización de nuevos fármacos inhibidores de la angiogénesis.
Enero 2014 - Diciembre 2017
Junta de Andalucía – FEDER
BIO2014-56092-R
Búsqueda de nuevas herramientas de intervención terapéutica para el control de la angiogénesis patológica.
Enero 2015 - Diciembre 2018
MINECO – FEDER
