Biocomputational and systems biology approaches to the study of angiogenesis-related diseases and rare diseases
Systems biology approaches, such as those offered by network science, are useful for the study of complex pathophysiological processes, such as cancer, other angiogenesis-dependent diseases and rare diseases in general. From this systems and network biology approach it is possible to predict new potential targets, which can be evaluated experimentally.
Aim
To use network systems biology to predict novel targets related to angiogenesis-dependent and rare diseases, as well as new repurpose uses of existing drugs for angiogenesis related diseases, and to test these predictions experimentally.
We make use of a variety of biological data mining, network analysis and biocomputational predictive tools to predict novel targets related to angiogenesis-dependent and rare diseases, as well as new repurpose uses of existing drugs for angiogenesis related diseases. The prediction can be tested experimentally making use of biochemical, molecular biology and omic approaches.
Deepening the knowledge of rare diseases dependent on angiogenesis through semantic similarity clustering and network analysis.
Pagano-Márquez, R., Córdoba-Caballero, J., Martínez-Poveda, B., Quesada, A.R., Rojano, E., Seoane, P., Ranea, J.A.G., & Medina, M.Á.
Briefings in Bioinformatics, 23(4), 1-15 (2022).
In silico prediction of targets for anti-angiogenesis and their in vitro evaluation confirm the involvement of SOD3 in angiogenesis.
García-Vilas, J. A., Morilla, I., Bueno, A., Martínez-Poveda, B., Medina, M. Á., & Ranea, J.A.G.
Oncotarget, 9(25), 17349-17367. (2018).
What is known on angiogenesis-related rare diseases? A systematic review of literature.
Rodríguez-Caso, L., Reyes-Palomares, A., Sánchez-Jiménez, F., Quesada, A. R., & Medina, M. Á.
Journal of Cellular and Molecular Medicine, 16(11), 2872-2893 (2012).
PI-0069-2022
Papel de los condensados biomoleculares en la patofisiología de las enfermedades raras.
Noviembre 2022 - Octubre 2025
Junta de Andalucía – FEDER
PID2019-105010RB-I00
Angiogenesis, inflammation and metabolism as therapeutic targets for pathological angiogenesis using biotechnological approaches.
Enero 2020 - Diciembre 2022
MICINN
BIO2014-56092-R
Búsqueda de nuevas herramientas de intervención terapéutica para el control de la angiogénesis patológica.
Enero 2015 - Diciembre 2018
MINECO – FEDER
