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Beatriz Martínez Poveda

After receiving my PhD in 2017 from the University of Malaga, with a Thesis focused on the identification of angiogenesis inhibitor molecules, I moved to Madrid, to the Alberto-Sols Biomedical Research Institute (IIB, CSIC-UAM) where I developed a project focused on the study of the development of hypoxia in tumor environments and its response to anti-angiogenic drugs, using in vivo imaging technologies in immunosuppressed animal models (2007-2009). Subsequently, I began a stage as a researcher at the National Center for Cardiovascular Research (CNIC, Madrid), working on several projects related to the characterization of the molecular basis of cardiovascular diseases, such as atherosclerosis, aortic stenosis and cardiomyopathies (2010-2015). I am currently Associate Professor at the University of Malaga, and my projects focus on the identification of natural and synthetic molecules affecting pathological microenvironment processes, with special interest in characterizing their molecular mechanisms of action.

Publications

  • Carrillo, P., Bernal, M., Téllez-Quijorna, C., Marrero, A. D., Vidal, I., Castilla, L., Caro, C., Domínguez, A., García-Martín, M. L., Quesada, A. R., Medina, M. A., & Martínez-Poveda, B. (2023). The synthetic molecule stauprimide impairs cell growth and migration in triple-negative breast cancer. Biomedicine & Pharmacotherapy, 158, 114070. https://doi.org/10.1016/j.biopha.2022.114070
  • Vidal, I., Castilla, L., Marrero, A. D., Bravo-Ruiz, I., Bernal, M., Manrique, I., R Quesada, A., Medina, M. Á., & Martínez-Poveda, B. (2022). The Sponge-Derived Brominated Compound Aeroplysinin-1 Impairs the Endothelial Inflammatory Response through Inhibition of the NF-κB Pathway. Marine drugs, 20(10), 605. https://doi.org/10.3390/md20100605
  • Marrero, A. D., Quesada, A. R., Martínez-Poveda, B., & Medina, M. Á. (2022). Antiangiogenic Phytochemicals Constituent of Diet as Promising Candidates for Chemoprevention of Cancer. Antioxidants (Basel, Switzerland), 11(2), 302. https://doi.org/10.3390/antiox11020302
  • Bravo-Ruiz, I., Medina, M. Á., & Martínez-Poveda, B. (2021). From Food to Genes: Transcriptional Regulation of Metabolism by Lipids and Carbohydrates. Nutrients, 13(5), 1513. https://doi.org/10.3390/nu13051513
  • MacGrogan, D., Martínez-Poveda, B., Desvignes, J. P., Fernandez-Friera, L., Gomez, M. J., Gil Vilariño, E., Callejas Alejano, S., Garcia-Pavia, P., Solis, J., Lucena, J., Salgado, D., Collod-Béroud, G., Faure, E., Théron, A., Torrents, J., Avierinos, J. F., Montes, L., Dopazo, A., Fuster, V., Ibañez, B., … de la Pompa, J. L. (2020). Identification of a peripheral blood gene signature predicting aortic valve calcification. Physiological genomics, 52(12), 563–574. https://doi.org/10.1152/physiolgenomics.00034.2020
  • Marrero, A. D., Castilla, L., Espartero, J. L., Madrona, A., R Quesada, A., Medina, M. Á., & Martínez-Poveda, B. (2020). A comparative study of the antiangiogenic activity of hydroxytyrosyl alkyl ethers. Food chemistry, 333, 127476. https://doi.org/10.1016/j.foodchem.2020.127476
  • Carrillo, P., Martínez-Poveda, B., Medina, M. Á., & Quesada, A. R. (2019). The strigolactone analog GR-24 inhibits angiogenesis in vivo and in vitro by a mechanism involving cytoskeletal reorganization and VEGFR2 signalling. Biochemical pharmacology, 168, 366–383. https://doi.org/10.1016/j.bcp.2019.07.019
  • Nus, M., Martínez-Poveda, B., MacGrogan, D., Chevre, R., D’Amato, G., Sbroggio, M., Rodríguez, C., Martínez-González, J., Andrés, V., Hidalgo, A., & de la Pompa, J. L. (2016). Endothelial Jag1-RBPJ signalling promotes inflammatory leucocyte recruitment and atherosclerosis. Cardiovascular research, 112(2), 568–580. https://doi.org/10.1093/cvr/cvw193
  • MacGrogan, D., D’Amato, G., Travisano, S., Martinez-Poveda, B., Luxán, G., Del Monte-Nieto, G., Papoutsi, T., Sbroggio, M., Bou, V., Gomez-Del Arco, P., Gómez, M. J., Zhou, B., Redondo, J. M., Jiménez-Borreguero, L. J., & de la Pompa, J. L. (2016). Sequential Ligand-Dependent Notch Signaling Activation Regulates Valve Primordium Formation and Morphogenesis. Circulation research, 118(10), 1480–1497. https://doi.org/10.1161/CIRCRESAHA.115.308077
  • D’Amato, G., Luxán, G., del Monte-Nieto, G., Martínez-Poveda, B., Torroja, C., Walter, W., Bochter, M. S., Benedito, R., Cole, S., Martinez, F., Hadjantonakis, A. K., Uemura, A., Jiménez-Borreguero, L. J., & de la Pompa, J. L. (2016). Sequential Notch activation regulates ventricular chamber development. Nature cell biology, 18(1), 7–20. https://doi.org/10.1038/ncb3280
  • Luxán, G., Casanova, J. C., Martínez-Poveda, B., Prados, B., D’Amato, G., MacGrogan, D., Gonzalez-Rajal, A., Dobarro, D., Torroja, C., Martinez, F., Izquierdo-García, J. L., Fernández-Friera, L., Sabater-Molina, M., Kong, Y. Y., Pizarro, G., Ibañez, B., Medrano, C., García-Pavía, P., Gimeno, J. R., Monserrat, L., … de la Pompa, J. L. (2013). Mutations in the NOTCH pathway regulator MIB1 cause left ventricular noncompaction cardiomyopathy. Nature medicine, 19(2), 193–201. https://doi.org/10.1038/nm.3046

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